IMMUNOGENICITY OF HEPATITIS A VACCINE IN CHILDREN WITH CANCER |
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Authors: | Yavuz Köksal Bilgehan Yalçin G Burça Aydın Neriman Sarı Nalan Yazici Ali Varan |
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Institution: | Department of Pediatric Oncology, Hacettepe University, Institute of Oncology, 06100, Ankara, Turkey |
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Abstract: | This study evaluated the immuned response of the hepatitis A vaccine in children with cancer who were receiving chemotherapy. Twenty-eight patients with lymphomas or solid tumors and who had negative serology for hepatitis A were enrolled. The median age was 4.7 years (range 2–16). The patients received 1440 IU hepatitis A vaccine at 0 and 6 months. Seroconversion rates at the first and seventh months were 60% (n = 17/28 patients) and 89% (n = 24/27 patients). No adverse effects were observed. The hepatitis A vaccine was found to be effective and safe in children with cancer. |
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Keywords: | cancer chemotherapy children hepatitis A vaccine |
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