OFF-LABEL USE OF GRANULOCYTE COLONY-STIMULATING FACTOR IN NONCONGENITAL NEUTROPENIA: Retrospective Data from the Italian Neutropenia Registry |
| |
| Authors: | Francesca Fioredda Michaela Calvillo Daniela Renga Sonia Bonanomi Andrea Ciliberti Baldassarre Martire |
| |
| Institution: | 1. Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, G. Gaslini Children's Hospital, Genova, Italy;2. Pediatric Department, University of Turin, Turin, Italy;3. Department of Pediatric Hematology-Oncology, University of Milano-Bicocca, S. Gerardo Hospital, Monza, Italy;4. Department of Pediatrics, “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Foggia, Italy;5. Department of Pediatrics, University of Bari, Bari, Italy |
| |
| Abstract: | This paper reviews a series of 70 consecutive children with rhabdomyosarcoma (RMS) diagnosed during 1971-1978 and treated in five Italian institutions. Thirteen were classified as group I, 12 as group II, 37 as group III, and 8 as group IV according to the Intergroup RMS Study staging system. Survival was influenced by tumor extension at diagnosis, primary site, and response to therapy. The 5-year-survival rate was 92% for group I patients, 67% for group II, 44% for group HI, and 0% for group IV. Thirty-four children had all therapy stopped after 12-32 months of complete remission, 7 had late recurrences, and 3 died from disease. Musculoskeletal sequelae were diagnosed in 11 children, short stature in 3, corneal opacity in 2, and cardiac failure in 1. |
| |
| Keywords: | rhabdomyosarcoma retrospective study of clinical results of late effects of |
|
|
