SIMULTANEOUS OCCURRENCE OF ADVANCED NEUROBLASTOMA AND ACUTE MYELOID LEUKEMIA |
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| Authors: | Telma M Santos-Machado Maria C Zerbini Lillian M Cristofani Paula Maria Azevedo Maria T A Almeida Paulo T Maluf Jr |
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| Institution: | 1. Hematology/Oncology Division, Children's Institute of the Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil;2. Department of Surgical Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil;3. Hemotology/Oncology Division, Children's Institute of Clinics Hospital, University of Sao Paulo Medical Sochool, Sao Paulo, Brazil;4. Pediatric Oncology Division, Hospital of Federal District, Sao Paulo, Brazil |
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| Abstract: | The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma (NB), who had been treated with 6 cycles of cyclophosphamide, doxorubicin, cisplatin, and etoposide for 12 months. The patient reached partial remission and presented a diagnosis of acute myelomonocytic leukemia (M4 AML), confirmed by immunophenotyping. After 2 months of therapy for leukemia, the child died with both malignancies in activity. A necropsy histologically confirmed the simultaneity of the two diseases. The authors review the possibilities of this association. The review leads to the conclusion that AML can occur as a secondary malignancy after the onset of the neuroblastoma, or be suggested by a misdiagnosis. The simultaneous occurrence of both as described here is not, however, found in the literature, to the best of the authors' knowledge. |
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| Keywords: | Acute Myeloid Leukemia Neuroblastoma Secondary Malignancy |
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