SUCCESSFUL TREATMENT OF ASPERGILLUS BRAIN ABSCESS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND LIVER FAILURE |
| |
| Authors: | Jaroslav Sterba Jaroslav Prochazka Jiri Ventruba Leos Kren Dalibor Valik Dagmar Burgetova |
| |
| Affiliation: | 1. Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic;2. Department of Pediatric Radiology, University Hospital Brno and Masaryk University, Brno, Czech Republic;3. Department of Paediatric Surgery, Traumatology and Orthopaedics, University Hospital Brno and Masaryk University, Brno, Czech Republic;4. Department of Pathology and Laboratory Medicine, University Hospital Brno and Masaryk University, Brno, Czech Republic;5. Department of Biochemistry, Masaryk Memorial Cancer Institute, Brno, Czech Republic;6. Department of Clinical Microbiology, University Hospital, Brno, Czech Republic |
| |
| Abstract: | Invasive fungal infection continues to pose a significant threat to immunocompromised patients, with cerebral aspergillosis being among the most feared ones. The authors describe an adolescent girl with acute lymphoblastic leukemia (ALL) with subsequent acute liver failure, who developed an aspergillus brain abscess. The patient was treated with combined antifungal therapy using amphotericin B local instillation, prolonged systemic amphotericin B colloidal dispersion along with vinca alkaloids-containing chemotherapy, followed by neurosurgical débridement and oral voriconazole in the setting of ongoing antileukemic maintenance chemotherapy. Her ALL remains now in complete remission 30 months from diagnosis, with no evidence of fungal infection. |
| |
| Keywords: | acute leukemia CNS aspergillosis liver failure treatment |
|
|
