LATE RESPONSE TO RADIOCHEMOTHERAPY IN PEDIATRIC GLIOBLASTOMA: Report on Two Patients Treated According to HIT-GBM Protocols |
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| Authors: | C. F. Classen M. Warmuth-Metz K. Papke A. Trotter J. E. A. Wolff S. Wagner |
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| Affiliation: | 1. Children's Hospital, Wedau Kliniken, Klinikum Duisburg, Duisburg, Germany;2. University Children's Hospital, Rostock, Germany;3. Department of Neuroradiology, University of Würzburg, Würzburg, Germany;4. Clinic of Radiology and Neuroradiology, Wedau Kliniken, Klinikum Duisburg, Duisburg, Germany;5. Hegau-Klinikum GmbH, Singen, Germany;6. M.D. Anderson Cancer Center of the University of Texas, Department of Pediatrics, Pediatric Neurooncology Section, Houston, Texas, USA;7. University of Regensburg, Department of Pediatric Oncology, Regensburg, Germany;8. University of Regensburg, Department of Pediatric Oncology, Regensburg, Germany |
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| Abstract: | High-grade gliomas in children are rare and the best treatment is undetermined. The German language group study HIT-GBM compares various induction protocols for subsequent patient cohorts. Currently, cisplatinum, etoposide, ifosfamide, and vincristine are given simultaneously with extended-field radiotherapy. Imaging is done 3 weeks after to define treatment response, followed by 6-weekly controls during consolidation with lomustine, vincristine, and prednisone. The authors report on 2 patients with incompletely resected glioblastoma multiforme in which response was lacking 3 weeks after radiochemotherapy but became evident 12 weeks later. This suggests that later time points are required to assess induction protocol response. |
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| Keywords: | glioblastoma response control radiochemotherapy pediatric |
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