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| Primary signet-ring cell carcinoma of the colon at early stage： A case report and a review of the literature | |
| 作者姓名： | Fu KI Sano Y Kato S Saito H Ochiai A Fujimori T Saito Y Matsuda T Fujii T Yoshida S |
| 作者单位： | Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East Kashiwa,Chiba 277-8577,Japan Department of Surgical and Molecular Pathology,Dokkyo University School of Medicine,880 Kitakobaysashi,Mibu,Shimotuga,Tochigi 321-0293,Japan,Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East,Kashiwa,Chiba 277-8577,Japan,Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East,Kashiwa,Chiba 277-8577,Japan,Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East,Kashiwa,Chiba 277-8577,Japan,Division of Pathology National Cancer Center East Research Institute,Chiba 277-8577,Japan,Department of Surgical and Molecular Pathology Dokkyo University School of Medicine,880 Kitakobaysashi,Mibu,Shimotuga,Tochigi 321-0293,Japan,Division of Endoscopy National Cancer Center Hospital,Tsukiji,Tokyo 104-0045,Japan,Division of Endoscopy National Cancer Center Hospital,Tsukiji,Tokyo 104-0045,Japan,Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East,Kashiwa,Chiba 277-8577,Japan,Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East,Kashiwa,Chiba 277-8577,Japan |
| 摘 要： | A 67-year-old man, who had undergone surgery to resect multiple gastric cancers 4 years ago, visited our hospital for surveillance colonoscopy. Colonoscopy revealed a discolored, 7-mm in diameter, flat-elevated lesion with central depression in the transverse colon near the splenic flexure. Although the findings of endoscopy and barium enema were suggestive of submucosal invasion, the patient chose to undergo endoscopic mucosal resection. Pathological examination of the resected specimen revealed signet-ring cell carcinoma and a positive surgical margin. A second operation was performed, and no residual tumor or metastasis to lymph nodes was found in the resected specimens. Primary colorectal cancers composed of signet-ring cell carcinoma detected and treated at an early stage are extremely rare. We present a case and review the literature. |
| 关 键 词： | 结肠癌 内窥镜检查 病理机制 临床 |
| 收稿时间： | 2005 Nov 9 |
Primary signet-ring cell carcinoma of the colon at early stage: a case report and a review of the literature |
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| Fu KI,Sano Y,Kato S,Saito H,Ochiai A,Fujimori T,Saito Y,Matsuda T,Fujii T,Yoshida S.Primary signet-ring cell carcinoma of the colon at early stage: a case report and a review of the literature[J].World Journal of Gastroenterology,2006,12(21):3446-3449. | |
| Authors: | Fu Kuang-I Sano Yasushi Kato Shigeharu Saito Hiroki Ochiai Atsushi Fujimori Takahiro Saito Yutaka Matsuda Takahisa Fujii Takahiro Yoshida Shigeaki |
| Institution: | 1. Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan;Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobaysashi, Mibu, Shimotuga, Tochigi 321-0293, Japan 2. Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan 3. Division of Pathology, National Cancer Center East Research Institute, Chiba 277-8577, Japan 4. Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobaysashi, Mibu, Shimotuga, Tochigi 321-0293, Japan 5. Division of Endoscopy,National Cancer Center Hospital, Tsukiji, Tokyo 104-0045, Japan |
| Abstract: | A 67-year-old man, who had undergone surgery to resect multiple gastric cancers 4 years ago, visited our hospital for surveillance colonoscopy. Colonoscopy revealed a discolored, 7-mm in diameter, flat-elevated lesion with central depression in the transverse colon near the splenic flexure. Although the findings of endoscopy and barium enema were suggestive of submucosal invasion, the patient chose to undergo endoscopic mucosal resection. Pathological examination of the resected specimen revealed signet-ring cell carcinoma and a positive surgical margin. A second operation was performed, and no residual tumor or metastasis to lymph nodes was found in the resected specimens. Primary colorectal cancers composed of signet-ring cell carcinoma detected and treated at an early stage are extremely rare. We present a case and review the literature. |
| Keywords: | Signet-ring cell carcinoma Early colorectal cancer Endoscopic mucosal resection |
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