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EFFECT OF RETINOIC ACID IN PSORIASIS, II |
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| Authors: | ANGUS MACDONALD R. M. H. McMINN LIONEL FRY |
| Affiliation: | Department of Dermatology, St Mary's Hospital, London, W.2 (Dr Angus Macdonald and Dr Lionel Fry);Department of Anatomy, Royal College of Surgeons of England, Lincoln's Inn Fields, London, W.C.2 (Professor R. M. H. McMinn) |
| Abstract: | Summary.— Clinical and histological features and mitotic counts have been studied in the lesions of 11 patients with psoriasis who were treated with topically applied retinoic acid ointment for a period of 3 months. Serial biopsies were taken at monthly intervals from treated lesions in all 11 patients and from lesions treated with the unmedicated ointment base in 9. There was no significant difference between treated and placebo groups regarding any of the parameters studied. Irritant effects of the retinoic acid were prominent in 7 patients. The significance of these results is discussed in the light of the known mechanism of action of retinoic acid. |
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