决明子乙酸乙酯提取物对非酒精性脂肪肝大鼠的防治作用

目的:观察决明子乙酸乙酯提取物对非酒精性脂肪肝大鼠的防治作用.方法:采用喂饲高脂饲料方法复制非酒精性脂肪肝大鼠模型,同时施加不同剂量的决明子乙酸乙酯提取物进行干预,以东宝肝秦片做对照,观察其对血清肝酶活性和肝脏组织病理学改变的影响.结果:决明子乙酸乙酯提取物能明显降低实验大鼠血清、肝脏组织中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和血清ALT,AST的含量,升高高密度脂蛋白胆固醇(HDL-C)的含量,改善肝脏的病理损害.结论:决明子乙酸乙酯提取物具有良好的降脂保肝作用.

Effects of the Acetoacetate Extraction from Semen Cassiae on Nonalcoholic Fatty Liver in Rats

Objective: To investigate the effects of aeetoaeetate extraction from Semen Cassiae on rats with nonalcoholic fatty liver. Method: The nonalcoholic fatty liver rat model was made by feeding high fat forage, and the acetoacetate extraction from Semen Cassiae in different dosages was given to the model to interfering the dis- sease. Dong-bao Gan-tai pellet was as control. And then observe hepat-enzymatic activity in blood serum and liver histopathology change. Result: The acetoaeetate extraction from Semen Cassiae could obviously decrease TC, TG and LDL-C in serum as well as ALT, AST in serum, increase HDL-C and improve the pathological damage. Con- clusion: The acetoacetate extraction from Semen Cassiae has favorable effect on blood lipid reduction and liver pro- tection.