Radiation dose enhancement therapy with iodine in rabbit VX-2 brain tumors |
| |
| Authors: | K S Iwamoto S T Cochran J Winter E Holburt R T Higashida A Norman |
| |
| Affiliation: | 1. Univ Rennes, ISCR (Institut des Sciences Chimiques de Rennes) – UMR 6226, F-35000, Rennes, France;2. CHU de Rennes, Pôle Hospitalo-Universitaire de Pharmacie, F-35033, Rennes, France;1. Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;2. China Institute of Atomic Energy, Beijing 102413, China;3. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China |
| |
| Abstract: | Loading tissue with iodine enhances the radiation dose absorbed from low energy X-rays. In order to test whether this is a useful procedure for treating brain tumors, we infused radiographic contrast media into rabbits carrying VX-2 brain tumors and delivered 15 Gy of 120 kVp X-rays in 3 fractions to the tumor. From CT scans we estimated that the dose enhancement was approximately 30%. The median survival times, after tumor detection on CT, of untreated rabbits, treated with radiation alone, and treated with radiation plus contrast media were 3, 25.5, 38.5 days, respectively. The repeated infusion of contrast media, 3.5 g of iodine per kg of body weight, did not affect kidney function as measured by serum creatinine levels. This method of enhancing radiation dose in brain tumors therefore appears promising. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
