Carrageenan oedema in copper-deficient rats |
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| Authors: | R. Milanino S. Mazzoli E. Passarella G. Tarter G. P. Velo |
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| Affiliation: | (1) Pharmacology Dept., Research Division, Laboratori Glaxo S.p.A., Duncan Farmaceutici S.p.A., Via A. Fleming 2, 37100 Verona, Italy;(2) Istituto di Farmacologia, University of Padova, Policlinico Borgo Roma, 37100 Verona, Italy |
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| Abstract: | Carrageenan-induced hind paw oedema has been studied in rats deprived of copper for different lengths of time.A common feature observed in normally fed and copper-deficient rats was the rise of serum copper levels coccurring between 10 and 24 h after the injection of the irritant.After 1 month of copper-deficient diet no differences are seen in the oedema developed by controls and copperdeprived animals, while after 3 months the oedema developed by copper-deficient rats was significantly greater compared with the controls.These results are briefly discussed. |
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