Antithrombogenic and Antiplatelet Activities of Extract from Maackia amyrensis Wood |
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| Authors: | A. M. Plotnikova Z. T. Shulgau T. M. Plotnikova O. I. Aliev N. I. Kulesh N. P. Mischenko S. A. Fedoreyev |
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| Affiliation: | (1) Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia;(2) Siberian State Medical University, Tomsk, Russia;(3) Pacific Institute of Organic Biochemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia |
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| Abstract: | Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats. Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 164-167, February, 2009 |
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| Keywords: | thrombosis ovariectomy isoflavonoids Maackia amyrensis extract ethinylestradiol |
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