| 硝唑咪有关化合物的合成 |
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| 引用本文： | 邓定安,陆顺兴. 硝唑咪有关化合物的合成[J]. 药学学报, 1981, 16(1): 14-18 |
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| 作者姓名： | 邓定安 陆顺兴 |
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| 作者单位： | 中国科学院上海药物研究所(邓定安)，中国科学院上海药物研究所(陆顺兴) |
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| 摘 要： | 本文报道合成了与硝唑味近似的酰胺类化合物七个,脲类化合物五个、四氢味唑酮类化合物三个、六氢嘧啶酮类化合物三个和缩氨基跣脲类化合物四个,供抗生育筛选,其中5-氯2-乙酰噻吩缩氨基硫脲具有抗早孕作用。
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| 收稿时间： | 1979-10-20 |
SYNTHESIS OF SOME COMPOUNDS RELATED TO NIRIDAZOLE |
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| Deng Dingan and Lu Shunxing. SYNTHESIS OF SOME COMPOUNDS RELATED TO NIRIDAZOLE[J]. Acta pharmaceutica Sinica, 1981, 16(1): 14-18 |
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| Authors: | Deng Dingan and Lu Shunxing |
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| Abstract: | In the present communication seven amides, five ureas, three 2-imidazolidinones, three hexahydro-2-pyrimidinones and four thiosemicarbazones, similar to niridazole were synthesized for antifertility evaluation. Preliminary Pharmacological results showed that 5-chloro-2-acetyl-thiophene thiosemicarbazone was effective in termination of early pregnancy in rats at a dose of 5 mg/Kg. |
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