小剂量胺碘酮预防老年人阵发性心房纤颤复发的疗效和安全性

目的：探讨口服小剂量胺碘酮（AD）预防老年人非瓣膜性心脏病阵发性房颤复发的疗效，方法：40例老年阵发性房颤忠者，给予AD600mg.d^-1，6d后渐减为维持量50－100mg.d^-1,24h动态心电图观察评价其疗效。结果：服药后6月，12 24月，AD维持窦性心律的有效率分别为90．0％，83．3％和72．7％，因副作用停药者仅5％（2／40），结论：小剂量AD（50－100mg.d^-1)可有效，安全的预防老年人阵发性房颤的复发。

Efficacy and safety of low dose amiodarone for paroxysmal atrial fibrillation in the aged patients with no-valvular heart diseases]

OBJECTIVE: To study the efficacy and safety of low-dose amiodarone (AD) for paroxysmal atrial fibrillation in the aged patients with no-valvular heart diseases. METHOD: 40 inpatients were treated with load-dose AD (600 mg.d-1) for 6 days and then low maintenance dose of 50 mg or 100 mg daily. Clinical efficacy was evaluated with 24 h dynamic electrocardiogram. RESULTS: AD maintained efficaciously sinus rhythm about 90.0% (36/40) during 6 months, about 83.3% (25/30) during 12 months, about 72.7% (16/22) during 24 months. Only 2 patients were stopped oral AD because sinus bradycardia(< or = 45 bpm) occurred. CONCLUSION: Low dose AD (50-100 mg.d-1) is a safe and efficient maintenance of sinus rhythm in aged patients with no-valvular heart diseases and paroxysmal atrial fibrillation.