Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla |
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Authors: | Birgit Simon Stephan Schmidt Carsten Lukas Jürgen Gieseke Frank Träber Dirk L Knol Winfried A Willinek Jeroen J G Geurts Hans H Schild Frederik Barkhof Mike P Wattjes |
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Institution: | 1. Department of Radiology, University Hospital of Bonn, Bonn, Germany 2. Neurologische Gemeinschaftspraxis Bonn, K?lnstra?e 480, Bonn, Germany 3. Department of Diagnostic and Interventional Radiology, St. Josef Hospital, University of Bochum, Bochum, Germany 4. Department of Radiology, MS Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands 5. Philips Medical Systems, Hamburg, Germany 6. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands 7. Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
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Abstract: | Objective To investigate the impact of a higher magnetic field strength of 3 Tesla (T) on the detection rate of cortical lesions in multiple sclerosis (MS) patients, in particular using a dedicated double inversion recovery (DIR) pulse sequence. Methods Thirty-four patients with clinically isolated syndromes or definite MS were included. All patients underwent magnetic resonance imaging (MRI) at 1.5 T and 3 T, including T2-weighted turbo spin echo (TSE), fluid-attenuated inversion recovery (FLAIR) and DIR sequences. All images were analysed for focal lesions categorised according to their anatomical location. Results The total number of detected lesions was higher at 3 T across all pulse sequences. We observed significantly higher numbers of lesions involving the cortex at 3 T using a DIR sequence. DIR at 3 T showed 192% more pure intracortical (p?<?0.001) and 30% more mixed grey matter-white matter lesions (p?=?0.008). No significant increase in cortical lesions could be detected on the FLAIR and T2-weighted images. Using the T2-weighted and FLAIR sequences, significantly more lesions could be detected at 3 T in the infratentorial, periventricular and juxtacortical white matter. Conclusion DIR brain MR imaging at 3 T substantially improves the sensitivity of the detection of cortical lesions compared with the standard magnetic field strength of 1.5 T. |
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