| 生长抑素区域动脉灌注对SAP鼠胰腺腺泡细胞凋亡的影响 |
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| 引用本文： | 高友兵,胡俊波,刘伟.生长抑素区域动脉灌注对SAP鼠胰腺腺泡细胞凋亡的影响[J].医学临床研究,2008,25(10):1769-1770. |
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| 作者姓名： | 高友兵 胡俊波 刘伟 |
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| 作者单位： | 1. 广州军区武汉总医院普通外科,武汉,430070
2. 华中科技大学附属同济医院普通外科,湖北,武汉430030 |
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| 摘 要： | 目的]探讨生长抑素区域动脉灌注对重症急性胰腺炎(SAP)大鼠胰腺腺泡细胞凋亡的影响.方法]SD大鼠64只,随机分为假手术组(A组),SAP组(B组),生长抑素外周静脉注射组(C组),生长抑素区域动脉灌注组(D组).测定各组大鼠的血清淀粉酶(Amy),观察胰腺病理变化,并检测胰腺腺泡细胞的凋亡率.结果]①制成SAP模型后,各组Amy水平显著上升,而C组和D组可使Amy下降,以D组下降更为明显.②C组和D组生长可使胰腺腺泡细胞凋亡率明显上升,胰腺病理损害程度减轻,以D组作用更强.结论]①生长押素可诱导SAP大鼠胰腺细胞凋亡,减轻胰腺病理损害,是治疗SAP的有效方法.②生长抑素区域动脉灌注是治疗SAP的增效途径.
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| 关 键 词： | 胰腺炎 急性坏死性 胰腺 脱噬作用 生长抑素/药理学 灌注 局部 大鼠 |
Effect of Regional Intra-arterial Infusion with Somatostatin on Apoptosis in Rats with Severe Acute Pancreatitis |
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| GAG You-bing,HU Jun-bo,LIU Wei.Effect of Regional Intra-arterial Infusion with Somatostatin on Apoptosis in Rats with Severe Acute Pancreatitis[J].Journal of Clinical Research,2008,25(10):1769-1770. |
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| Authors: | GAG You-bing HU Jun-bo LIU Wei |
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| Institution: | GAO You-bing,HU Jun-bo,LIU Wei(Department of General Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030,China) |
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| Abstract: | Objective]To study the effects of regional intra-arterial infusion with somatostatin on apoptosis in rats with severe acute pancreatitis(SAP).Methods]SD rats were divided into four groups randomly:Sham-operative group(group A),SAP group(group B),group of peripheral vessel infusion of somatostatin(group C),group of regional intra-arterial perfusion of somatostatin(group D).The contents of serum amylase and pancreatic histologic changes were observed and apoptosis of pancreatic acinar cells was detected by ... |
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| Keywords: | pancreatitis acute necrotizing pancreas apoptosis somatostatin/PD perfusion regional rats |
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