| Survivin、MDR1、MRP在非小细胞肺癌中的表达及意义(英文) |
| |
| 作者单位： | Donghua Liu1，Xiazhi Zhang1，Xingwu Chen1，Fan Zhang2，Zhiwei Lu1，Yifeng Jin1，Linming Lu2 1 Department of Respiratory Medicine，Yijishan Hospital of Wannan Medical College，Wuhu 241001，China 2 Department of Pathology，Yijishan Hospital of Wannan Medical College，Wuhu 241001，China |
| |
| 摘 要： | Objective:To investigate the expressions and significance of Survivin,MDR1 and MRP in non-small cell lung cancer(NSCLC).Methods:Immunohistochemical staining was used to detect the expressions of Survivin,MDR1 and MRP.The correlation between the results was assessed and the impact of Survivin on prognoses was also examined.Results:Survivin was expressed in 78% tissues from NSCLC patients but not found in tissues from control patients(P < 0.05).The expression of Survivin was related to the tissue differentiation stage and lymph nodes metastasis of lung cancer.The mean survival time was shorter in patients with Survivin-expression than those who not.There was a significant correlation between MDR1 and Survivin(P < 0.05),whereas no close correlation was found between MRP and Survivin.Conclusion:(1) Survivin is of critical importance in the development of NSCLC,thus may provide an novel therapeutic target for lung cancer;(2) MDR1 and MRP present in tissues from lung cancer synergistically with Survivin,which might be involved in tumour resistance.
|
Expressions and significance of Survivin,MDR1 and MRP in non-small cell lung cancer (NSCLC) |
| |
| Authors: | Donghua Liu Xiazhi Zhang Xingwu Chen Fan Zhang Zhiwei Lu Yifeng Jin Linming Lu |
| |
| Institution: | Donghua Liu1,Xiazhi Zhang1,Xingwu Chen1,Fan Zhang2,Zhiwei Lu1,Yifeng Jin1,Linming Lu2 1 Department of Respiratory Medicine,Yijishan Hospital of Wannan Medical College,Wuhu 241001,China 2 Department of Pathology,Yijishan Hospital of Wannan Medical College,Wuhu 241001,China |
| |
| Abstract: | Objective:To investigate the expressions and significance of Survivin,MDR1 and MRP in non-small cell lung cancer(NSCLC).Methods:Immunohistochemical staining was used to detect the expressions of Survivin,MDR1 and MRP.The correlation between the results was assessed and the impact of Survivin on prognoses was also examined.Results:Survivin was expressed in 78% tissues from NSCLC patients but not found in tissues from control patients(P < 0.05).The expression of Survivin was related to the tissue differentiation stage and lymph nodes metastasis of lung cancer.The mean survival time was shorter in patients with Survivin-expression than those who not.There was a significant correlation between MDR1 and Survivin(P < 0.05),whereas no close correlation was found between MRP and Survivin.Conclusion:(1) Survivin is of critical importance in the development of NSCLC,thus may provide an novel therapeutic target for lung cancer;(2) MDR1 and MRP present in tissues from lung cancer synergistically with Survivin,which might be involved in tumour resistance. |
| |
| Keywords: | non-small cell lung cancer(NSCLC) Survivin drug-resistant protein |
| 本文献已被 CNKI 等数据库收录！ |
|
