益生菌与红霉素治疗早产儿喂养不耐受临床疗效对比分析

目的观察益生菌与红霉素治疗早产儿喂养不耐受的临床疗效、不良反应发生情况,探讨早产儿喂养不耐受的治疗方法。方法将93例喂养不耐受的早产儿随机分为常规组30例、红霉素组32例和益生菌组31例。常规组单纯给予常规治疗,红霉素组在常规治疗基础上加用红霉素治疗,益生菌组在常规治疗基础上加用益生菌治疗。观察并比较3组临床有效率、胃肠道症状消失时间、达到全胃肠喂养时间、恢复至出生体质量时间及腹泻、便秘发生情况。结果益生菌组和红霉素组有效率高于常规组,胃肠道症状消失时间、达到全胃肠喂养时间、恢复至出生体质量时间短于常规组;益生菌组腹泻、便秘发生率低于红霉素组和常规组,差异均有统计学意义(P<0.05和P<0.01)。除腹泻、便秘发生率外,益生菌组和红霉素组其他观察指标比较差异均无统计学意义(P>0.05)。结论益生菌与红霉素治疗早产儿喂养不耐受均有较好疗效,但红霉素在治疗过程中腹泻、便秘相对明显,在无胃肠道发育畸形的情况下,益生菌更有利于早产儿胃肠系统的生长发育。

The comparative analysis of clinical efficacy of probiotics and erythromycin to feeding intolerance in preterm infants

Objective Observed the clinical efficacy and adverse events of Probiotics and erythromycin to feeding intolerance in preterm infants,and explore the treatment of that.Methods 93 preterm infants were divided into conventional group of 30 cases,erythromycin group of 32 cases and probiotics group of 31 cases.The conventional group received routine treatment.Based on the conventional group,the erythromycin group were added with erythromycin,and the probiotics group were added with probiotics.Observed and compared the clinical effective rate,gastrointestinal symptoms losing time,time to reach full gastrointestinal feeding,time to return to birth weight and condition of diarrhea and constipation occurrence of 3 groups.Results The effective rate of the probiotics group and erythromycin group was higher than that of the conventional group,the gastrointestinal symptoms losing time,time to reach full gastrointestinal feeding and time to return to birth weight of the probiotics group and erythromycin group were lower than that of the conventional group;the incidence of diarrhea and constipation of the probiotics group was lower than that of the erythromycin group and the conventional group,the differences were statistically significant（P0.05）.Conclusion Both of probiotics and erythromycin in preterm infants to feeding intolerance have good effect,but the diarrhea and constipation are relatively obvious in the course of treatment in the erythromycin group.In the case of non-gastrointestinal tract developmental abnormalities,probiotics might be more helpful for the growth and development of the gastrointestinal system of the preterm infants.