| 大脑中动脉阻塞后脑组织病变过程及MDA含量变化 |
| |
| 引用本文： | 刘家骝,曹序茂.大脑中动脉阻塞后脑组织病变过程及MDA含量变化[J].中国病理生理杂志,1991,7(5):546-548. |
| |
| 作者姓名： | 刘家骝 曹序茂 |
| |
| 作者单位： | 贵州省老年医学研究所
(刘家骝，杨桂萍，贺晓燕，何燕，查力)，贵阳医学院病理教研室
(曹序茂)，贵阳医学院病理教研室(邓传静) |
| |
| 摘 要： | 在大鼠中用热凝造成大脑中动脉阻塞而致脑局灶性缺血。电镜观察发现,在缺血2min后,神经细胞粗面内质网与线粒体即出现改变。光镜检查,缺氧10min后才出现神经细胞缺血改变;梗死灶周边微血管体积密度在缺血24h后即明显升高。肉眼检查,于缺血3h后可见梗死灶。在缺血2min后,脑组织内丙二醛(MOA)即升高,说明在缺血缺氧的早期,脂质过氧化作用加强。表明自由基在缺血性脑损伤早期即起重要作用。
|
| 关 键 词： | 脑缺血 丙二醛 大鼠 |
Pathological changes and MDA content of the rat brain in the early stage of middle cerebral artery occlusion |
| |
| Liu Jia-Liu,Cao Xu-Mao,et al.Pathological changes and MDA content of the rat brain in the early stage of middle cerebral artery occlusion[J].Chinese Journal of Pathophysiology,1991,7(5):546-548. |
| |
| Authors: | Liu Jia-Liu Cao Xu-Mao |
| |
| Institution: | Liu Jia-Liu,Cao Xu-Mao,et al Department of Pathology,Guiyang Medical College and Guizhou Geriatrics Institute,Guiyang |
| |
| Abstract: | This paper reports the pathological changes and MDA content of the brain tissue in the early stage of cerebral ischemia due to middle cerebral artery occlusion (MCAO) in Wistar rats. The neurones showed changes of the rough endopiasmic reticulum and the mitochondrium as early as 2 minutes after MCAO. Under the light microscope, "ischemsc cells" with shrunken and condensed cytoplasm and nucleus appeared 10 minutes after MCAO. The end-product of lipid peroxidation, MDA, in the isch. emic brain tissue also significantly increased 2 minutes after MCAO, being correlated synchronously with the ultrastructural changes of the neurones. This suggested that free radicals play a role in the early stage of brain injury due to ischemia. |
| |
| Keywords: | Brain ischemia Malondialdehyde Rats |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
