| 沙土鼠短暂性脑缺血后海马迟发性神经元死亡机理的研究 |
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| 引用本文： | 尹翠芬,李麟仙.沙土鼠短暂性脑缺血后海马迟发性神经元死亡机理的研究[J].中国病理生理杂志,1991,7(6):605-608. |
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| 作者姓名： | 尹翠芬 李麟仙 |
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| 作者单位： | 昆明医学院病理生理学教研室
(尹翠芬，李麟仙)，昆明医学院病理生理学教研室(王子灿) |
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| 摘 要： | 本实验通过结扎沙土鼠双侧颈总动脉20分钟后再灌流2天或7天造成海马迟发性神经元死亡(DND)模型,检测背侧海马Ca~(2 )及脂质过氧化物含量的变化,并用海马CA_1区神经元密度作为指标,观察尼莫地平及超氧化物歧化酶(SOD)对海马DND的影响。结果:再灌流2天后背侧海马组织Ca~(2 )及MDA含量增加;尼莫地平及SOD均可改善海马CA_1区DND,使海马CA_1区神经元密度增加。本实验提示:Ca~(2 )及氧自由基导致的脂质过氧化物在短暂性脑缺血后海马DND的发生中起重要作用,钙拮抗剂及自由基清除剂对海马DND有保护作用。
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| 关 键 词： | 脑缺血 海马 神经元 |
Studies on the mechanism responsible for delayed neuronal death in hippocampus after transient cerebral ischemia in gerbils |
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| Yun Cui-Fen,Li Lin-Xian,et al.Studies on the mechanism responsible for delayed neuronal death in hippocampus after transient cerebral ischemia in gerbils[J].Chinese Journal of Pathophysiology,1991,7(6):605-608. |
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| Authors: | Yun Cui-Fen Li Lin-Xian |
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| Institution: | Yun Cui-Fen,Li Lin-Xian,et al Department of Pathophysiology,Kunming Medical college,Kunming |
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| Abstract: | DND in the gerbil hippocampus was performed by bilateral occlusion of carotid arteries for 20 min followed by reperfusion 2 or 7 days. The contents of Ca~(2 ) and MDA in drosal hippocampus were measured after two days reperfusion. Neuronal density in CA1 sector of hippocampus was used as an parameter. Effects of nimodipine and Superoxide dismutase (SOD) on DND in hippocampus were observed after 7 days reperfusion.The results indicated that the levels of Ca~(2 ) and MDA were increased significantly. DND in hippocampal CA1 sector was ameliorated by both nimodipine and SOD significantly. It was suggested that Ca~(2 ) and Iipid peroxidation play an important role in the development of DND hippocampus after transient forebrain ischemia in gerbils. Calcium Antagonist and free radical scavenger have obvious protective effects on DND in hippocampus. |
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| Keywords: | Transient cerebral ischemia Hippocampus Delayed neuronal death Lipid peroxidation |
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