Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients |
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| Authors: | Ben-Ali Meriem Barbouche Mohamed-Ridha Bousnina Soufia Chabbou Abdellatif Dellagi Koussay |
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| Institution: | Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia. |
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| Abstract: | Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis. |
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