小儿脓毒症相关性脑病的临床诊断与治疗探讨

目的 探讨脓毒症相关性脑病患儿的早期临床诊断与治疗策略.方法 对9例脓毒症相关性脑病患儿,根据其临床表现,按个体化原则采用早期综合加强策略控制脓毒症外,尽早大剂量血浆、丙种球蛋白(IVIG)调整免疫平衡,并加用小剂量甘露醇、鲁米那等保护脑功能并积极控制抽搐状态.结果 9例脓毒症患儿存活6例,死亡3例.结论 针对脓毒症复杂的病理生理和免疫失衡,运用早期综合加强策略控制脓毒症,防止多器官功能不全加重,早期诊断和治疗脓毒症相关性脑病,可显著提高存活率,降低病死率.

The clinical diagnosis and therapy of sepsis-associated encephalopathy in children

Objective To approach the strategy of clinical diagnosis and therapy of sepsis-associated encephalopathy(SAE) in children early. Methods Nine children accepted combination therapy,inclding large blood plasm and IVIG to adjust immunologic balance,mannitol and lunimmal to control spasm of SAE. Results 6 patiens were cured and 3 patiens died. Conclusion Using early combination therapy to sepsis and invent the aggravation of multiple organ dysfunction syndrome,diagnosing early and therapiing of SAE in children can raise survival rate and reduce death rate.