家兔急性氨中毒时体感诱发电位的变化

目的：探讨高血氨对神经传导及兴奋功能的影响。方法：观察家兔腔注入复方氯化铵溶流后，体感诱发电位（ＳＥＰ）和外周感觉神经传导速度（ＳＣＶ）的变化。结果：注入复方氯化争溶液后，ＳＥＰ各成分峰潜伏期均延长，以Ｐ１２和Ｎ１５延长最明显，峰间潜伏期Ｎ９－Ｐ１２和Ｐ１２－Ｎ１５亦延长，严重高氨血症时，Ｐ１２和Ｐ１５的振幅减小，但ＳＣＶ无显著改变，结论：急性氨中毒可使中枢内神经传导发生延缓和神经元的兴功能出现异

CHANGES OF SOMATOSENSORY EVOKED POTENTIAL DURING ACUTE AMMONIA INTOXICATION IN RABBITS

Objective: The present study was performed to explore the effect of hyperammonemia on neural conductivity and neuronal excitability in the somatosensory system. Methods: After intra intestinal administration of compound NH 4Cl solution, changes of somatosensory evoked potential(SEP) and sensory nerve conductive velocity(SCV) were observed in rabbits. Results:SEP changes after the administration were characterized by prolongation of latencies of all components, especially the cerebral components of P12 and N15, and by prolongation of inter-peak latencies of N9 P12 and P12 N15. The amplitudes of P12 and N15 were decreased in severe hyperammonemia, but SCV was not changed.Conclusion: Conductivity and excitability of the central part of the somatosensory pathway were involved in hyperammonemia,and the disfunction in the cerebral cortex was more serious than that of the subcortex structures.