| 爬行动物的体液免疫 |
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| 引用本文： | 林树柱,张连峰. 爬行动物的体液免疫[J]. 中国比较医学杂志, 2007, 17(11): I0005-I0007 |
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| 作者姓名： | 林树柱 张连峰 |
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| 作者单位： | 中国医学科学院实验动物研究所,北京协和医学院比较医学中心,北京,100021 |
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| 基金项目： | 科技部科研院所技术开发研究专项基金 |
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| 摘 要： | 爬行动物针对颗粒性和可溶性抗原,能够快速、有效的产生抗体。爬行动物血清中的抗体主要包括高分子量的免疫球蛋白(HMWIg)和不止一种的低分子量免疫球蛋白(LMWIg),爬行动物中还有在亲代和子代间传递的免疫球蛋白Ig Y。目前爬行动物免疫球蛋白的纯化方法主要有:硫酸铵沉淀法、联合凝胶过滤层析和离子交换层析法、Protein A亲和层析法。研究爬行动物体液免疫对研究动物免疫的进化及对病原控制具有重要意义。
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| 关 键 词： | 爬行动物 体液免疫 免疫球蛋白 纯化 |
| 文章编号： | 1671-7856（2007）11-S3-03 |
Humoral Immunity in Reptiles |
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| LIN Shu-zhu,ZHANG Lian-feng. Humoral Immunity in Reptiles[J]. Chinese Journal of Comparative Medicine, 2007, 17(11): I0005-I0007 |
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| Authors: | LIN Shu-zhu ZHANG Lian-feng |
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| Affiliation: | Institute of Laboratory Animal Science, Chinese Academy of Medical Science, Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China |
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| Abstract: | The reptiles can generate prompt and powerful antibody response to either soluble or particulate antigens.High molecular weight immunoglobulin and more than one low molecular weight immunoglobulins have been found in the serum of the reptiles.Transmission of specific immunoglobulins(IgY) from mothers to their offspring via the egg has been proven recently.Salt out of saturated(NH_4)_2SO_4,exclusion chromatography,ion exchange chromatography and protein A affinity chromatography were usually used in the purification for immunoglobulins of reptiles.The research for Humoral immunity in reptiles has significance to the evolution of animal immunology and the control for pathogeny. |
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| Keywords: | Reptiles Humoral immunity Immunoglobulin Purification |
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