| 糖尿病中的氧化损伤与抗氧化研究进展 |
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| 引用本文： | 杨前勇,邹大进. 糖尿病中的氧化损伤与抗氧化研究进展[J]. 国际内分泌代谢杂志, 2006, 26(Z1): 8-10 |
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| 作者姓名： | 杨前勇 邹大进 |
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| 作者单位： | 200433,上海,第二军医大学附属长海医院内分泌科 |
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| 摘 要： | 活性氧簇(ROS)引起的氧化损伤在糖尿病并发症的发病机制中起重要作用,最新研究显示线粒体ROS增加可能是糖尿病并发症发病的共同基础。ROS催化脂质、蛋白质／氨基酸及DNA 所形成的某些化学性质相对稳定的产物,有望成为反映氧化损伤的理想生物标志。近来发现噻唑烷二酮类药物、瑞格列奈、他汀类药物、血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂和钙通道阻滞剂兼有较强的抗氧化活性,有助于防治糖尿病并发症。
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| 关 键 词： | 活性氧簇 氧化应激 糖尿病 抗氧化剂 糖尿病并发症 |
| 修稿时间： | 2005-08-29 |
Oxidative damage and antioxidant treatment in diabetes mellitus |
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| YANG Qian-yong,ZOU Da-jin. Oxidative damage and antioxidant treatment in diabetes mellitus[J]. International JOurnal of Endocrinology and Metabolism, 2006, 26(Z1): 8-10 |
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| Authors: | YANG Qian-yong ZOU Da-jin |
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| Abstract: | Reactive oxygen species (ROS) plays a major role in the development and progression of diabetes and its complications. Recent studies show hyperglycemia-induced mitochondrial overproduction of ROS seems to be the unifying mechanism of diabetic complications. Some new specific oxidation products may be exploited as reliable biomarkers of oxidative stress. It has been proved that thiazolidinediones, repaglinide, statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor antagonist and calcium channel blockers have strong intracellular antioxidant activities and contribute to the prevention of diabetic complications. |
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| Keywords: | Reactive oxygen species Oxidative stress Diabetes Antioxidants Diabetic complications |
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