P-选择素与静脉血栓栓塞症

血小板激活是静脉血栓形成的重要组成步骤,P-选择素是血小板的活性受体,也能被上皮细胞所识别.作为血小板/内皮细胞活化标志和细胞黏附受体.其可通过介导血小板、内皮细胞黏附及与白细胞的相互作用,启动参与包括炎症和血栓形成等多种病理生理起始过程,是血栓形成的重要介质和靶分子.检验P.选择素可以通过流式细胞仪检测血小板表面的P一选择素或通过酶联免疫吸附试验检测血液中可溶性P-选择素,方法简便,这些数据可作为血小板激活的判断.从而为血栓形成提供依据.抑制P一选择素及其配体的结合,可使病理状态下血栓局部白细胞聚集减少,细胞因子及组织因子表达降低,纤维蛋白生成减少,从而有助于抑制血栓的形成.

P-seIectjn and Venous thromboembolism

Activated platelets are key components in many arterial disorders.p-seIectin is an activation-dependent platelet receptor,which is also identified in endothelial cells.This transmembrane protein has continued to attract great interest as it supports rapid and reversible cell adhesion in flow svstems and thus plays an essential role in multicellular interactions during thrombosis.For diagnostic purposes,P-seiectin can readily be detected on the platelet surface by flow cytometry and by ELISA as a soluble ligand m the plasma'and these data bear clinical significance in the pathogenesis of venous thrombosis.The inhibition of interaction of P-selectin with the ligand could downregulate cytokine and tissue factor expression and repress recruitment of leukocytes.