c-erbB-2表达在胃癌预后作用中的meta分析

目的探讨c—erbB-2的表达与胃癌患者各临床病理参数及预后的关系。方法选取1999年10月-2001年5月在本院实施原发胃癌切除术，且临床资料和随访资料均完整的患者56例，用免疫组化sP法检测c—erbB-2的表达。分析其与胃癌患者各生物学行为参数的关系，以生存作为患者的预后指标，用COX比例风险回归模型分析c—erbB-2在胃癌预后中的作用。结果研究结果显示：c-erbB-2在胃癌患者中的阳性表达率为19．6％，其表达与患者的年龄、性别、肿瘤大小及组织学分级等无明显关系，而与浆膜浸润、淋巴结转移、临床分期等密切相关；预后分析表明：c—erbB-2阳性组和阴性组患者的5年生存率分别为36％和55％，差异有统计学意义（P〈0．05）；COX单因素、多因素分析显示：c—erbB-2蛋白表达和淋巴结转移是影响胃癌患者预后的独立因素，且预后较差。结论c—erbB-2过度表达可以作为胃癌预后一个新的、独立的预测指标。并有望成为胃癌抗肿瘤治疗的新靶点。

Meta-Analysis of expression of c-erbB-2 in prognosis in gastric carcinom

Objective To discuss the relationship between prognostic significance of c-erbB-2 expression and all clinical stage pathologic indexes in gastric carcinoma. Methods The immunohistochemical method was used to detect the expression of c-erbB-2 in gastric carcinomas. The time of follow-up for all cases was more than 5 years and the clinical data were sufficient. Survival was supposed as the prognostic index.The relation between the prognostic significance of c-erbB-2 and the clinicopathological parameters in gastric carcinoma was analyzed.Results The over-expression of c-erbB-2 was 19.6% in 56 primary gastric carcinoma. There was no significant association among c-erbB-2 staining,sex,age,tumor size or histological type of the carcinoma. C-erbB-2-positive tumors were more likely to be associated with serosal invasion, nodal involvement and TNM stage. The analysis of prognosis showed： 5-year survival rates of the c-erbB-2 protein-positive and the protein-negative group were 36% and 55% respectively. The difference between two groups was significant （P〈0.05）.COX univariate and multivariate analyses indicated that the expression of c-erbB-2 and nodal metastasis were indicator of poor short-term survival.Conclusion The over-expression of c-erbB-2 can be considered as a new independent prognostic parameter for overall survival in gastric carcinoma. C-erbB-2 may be a promising target for anti-tumor therapy in gastric carcinoma.