Antinociceptive activity of Ricinus communis L. leaves |
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| Authors: | Dnyaneshwar J Taur Maruti G Waghmare Rajendra S Bandal Ravindra Y Patil |
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| Affiliation: | 1.Department of Pharmacognosy, SVPM''s College of Pharmacy, Malegaon (bk), Baramati, Maharashtra, India;2.Department of Pharmaceutical Chemistry, SVPM''s College of Pharmacy, Malegaon (bk), Baramati, Maharashtra, India;3.Department of Pharmacognosy, PDEA''s Shankarrao Ursal College of Pharmaceutical Sciences and Research Center, Kharadi, Pune-411014, Maharashtra, India |
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| Abstract: | ObjectiveTo evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL).MethodsAntinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw.ResultsThe results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids.ConclusionsIt can be concluded that MRCL possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it. |
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| Keywords: | Ricinus communis Analgesic Antinociceptive Writhing Formalin |
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