认知功能电话问卷修订版在认知功能损害早期测查中的应用

目的　检测认知功能电话问卷修订版 (TICS m)在认知功能损害早期测查时的信度和效度。方法　认知功能损害组患者 64例,对照组为社区健康老人 52名。由 2名神经科医师独立、盲法检查TICS m。做操作者工作特征(ROC)曲线,计算诊断效度。结果　TICS m各部分面访与电话访问的Pearson相关系数在 0 79~0 96之间,重测信度Pearson相关系数在 0 89 ~0 98之间。TICS m诊断痴呆( <28分)和轻度认知功能损害( <33分)的敏感性分别为 99%和 89%,特异性为 90%和92%,优于细微精神状态检查(MMSE)。TICS m总分和记忆力部分的敏感性较高。结论　TICS m具有很好的信度和效度,可用于认知功能损害早期的临床和流行病学筛查。TICS m对早期认知功能损害的诊断效度优于MMSE。

Telephone interview for cognitive status-modified used in screening cognitive impairment

Objective To observe the reliability and validity of the Chinese version of Telephone Interview for Cognitive Status-Modified (TICS-m) in screening earlier stage of cognitive impair-ment. Methods 64 cognitive impairment patients and 52 community-dwelling healthy eldly individuals were assessed. TICS-m was examined blindly by two independent neurological doctors. The sensitivity and specificity were calculated by Receiver Operating Characteristic Curve (ROC).Results The correlation between face-to-face and telephone interviews was high. The spearman correlation coefficient of reliability was 0.89-0.98. The sensitivities to identify dementia (<28) and mild cognitive impairment (MCI) (<33) were 99% and 89% respectively. The sensitivities of TICS-m and the memory factor score were both high.Conclusions Face-to-face and telephone interviews of TICS-m were highly correlated. Inter-rater reliability and intra-rater reliability were good. The TICS-m is valid and reliable when used to screen earlier period of cognitive impairment, and better than MMSE.