盐酸安非他酮治疗抑郁与焦虑障碍的临床观察

目的研究安非他酮治疗抑郁症和焦虑症的临床疗效。方法将30例抑郁症患者和20例焦虑症患者分别给予安非他酮治疗,疗程6周。采用汉密顿抑郁量表(HAMD)评定临床疗效。结果治疗30例抑郁症中,痊愈率可达80%;对双相情感障碍抑郁发作更有效,10例中9例痊愈,且无转躁现象,而其他三环抚抑郁药和新型抗抑郁药常诱发躁狂发作。结论安非他酮是治疗抑郁症和焦虑症的有效药物,甚至优于其他新型抗抑郁药物。临床发现新型抗抑郁药如5-HT再摄取抑制剂和SNRI类如文拉法辛等所致恶心、头胀、紧张、嗜睡等副反应较常见,一定程度上影响其临床应用。盐酸安非他酮治疗应用中发现其抗抑郁和抗焦虑作用与上述新型抗抑郁药相似,且不良反应用较少。可作为首选药物。

Bupropion Hydrochloride for Clinical Treatments of Depression and Anxiety Disorder

Objective To clinically analyze and discuss its curative efficacy on out-patients with depression(n=30)and/or anxiety disorders(n=20).Method out-patients with depression and/or anxiety disorders were respectively treated with bopropion.The period of study was 6 weeks.The efficacy was measured with Hamilton Depression Rating Scale(HAMD).Rasult The result showed that bupropion was an effective drug in treatment of depression and anxiety disorders,being even more active than other kinds of antidepressants.Of t...