| 青年乳腺癌VEGF和EGFR的表达及其与临床病理的关系 |
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| 引用本文： | 廖佳建,叶长生,刘民锋,甄乐峰.青年乳腺癌VEGF和EGFR的表达及其与临床病理的关系[J].重庆医学,2010,39(13). |
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| 作者姓名： | 廖佳建 叶长生 刘民锋 甄乐峰 |
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| 作者单位： | 南方医科大学南方医院乳腺中心,广州,510515;南方医科大学南方医院乳腺中心,广州,510515;南方医科大学南方医院乳腺中心,广州,510515;南方医科大学南方医院乳腺中心,广州,510515 |
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| 摘 要： | 目的 探讨青年乳腺癌患者血管内皮生长因子(VEGF)和表皮生长因子受体(EGFR)表达情况以及与临床特点和病理学特征的关系.方法 收集67例临床病理资料完整的青年乳腺癌病例(年龄在35岁以下),用免疫组织化学方法检测癌组织中VEGF及EGFR的表达情况,并与患者TNM分期、腋淋巴结转移状况进行比较分析,选取同期35岁以上中老年妇女乳腺癌患者410例进行对照.结果 青年组乳腺癌VEGF及EGFR的阳性表达率分别为61.19%及64.18%,中老年组分别为41.46%及40.24%.青年组VEGF阳性率显著高于中老年组,差异有统计学意义(P＜0.01);EGFR阳性率也显著高于后者,差异有统计学意义(P＜0.01),VEGF、EGFR与TNM分期、腋淋巴结转移数目呈正相关,差异有统计学意义(P＜0.05),随着TNM分期增加及腋淋巴结转移数目的 增多,二者阳性表达率显著升高.结论 青年乳腺癌侵袭性强、预后差可能与癌组织中VEGF及EGFR的高表达有关;测量乳腺癌组织中VEGF及EGFR的表达情况对判断乳腺癌预后及指导治疗有一定的参考意义.
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| 关 键 词： | 乳腺癌 青年 血管内皮生长因子 表皮生长因子受体 |
Relationship between expressions of VEGF and EGFR of breast cancer with clinical pathology in young patients |
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| LIAO Jia-jian,YE Chang-sheng,LIU Min-feng,et al..Relationship between expressions of VEGF and EGFR of breast cancer with clinical pathology in young patients[J].Chongqing Medical Journal,2010,39(13). |
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| Authors: | LIAO Jia-jian YE Chang-sheng LIU Min-feng |
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| Institution: | LIAO Jia-jian,YE Chang-sheng,LIU Min-feng,et al.(Department of Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China) |
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| Abstract: | Objective To study the expressions of VEGF and EGFR in young patients with breast cancer,and the correlation between their expressions and clinicopathological characteristics.Methods The expressions of VEGF and EGFR in 67 young patients with breast cancer(under 35-year-old) recent years were detected by using immunohistochenical method,and the relationship of the clinical pathology such as tumor TNM staging,axillary lymph node metastasis and biological characteristics were compared and analyzed.Another 410 ... |
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| Keywords: | breast cancer Young patients vascalia endothelial grouth factor epidermal grouth factor receptor |
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