| Observation of intratumoral injection of radiosensitizer |
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| 作者姓名： | 徐德门 孙国彦 孙朝阳 |
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| 作者单位： | Radiotherapy Center Xijing Hospital，Fourth Military Medical University，Xi'an 710032，Radiotherapy Center，Xijing Hospital，Fourth Military Medical University，Xi'an 710032，Radiotherapy Center，Xijing Hospital，Fourth Military Medical University，Xi'an 710032 |
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| 摘 要： | The present study made in 92 mice showed that hydrogen peroxide com-pound injected directly into the tumor could to some extent sensitize the hypoxiccells of S180 solid tumor to radiate,for example,both the tumor regression rateand the mouse survival rate 40d after radiation in the hydrogen peroxide com-pound group were significantly greater than those in the radiation alone group.The increasing rate of tumor diameter in 10d was 77.10%,47.09%,and 47.47%-10.4% in groups of control,radiation alone,radiosensitizer alone,radiationand hydrogen peroxide compound,respectively.Some of the problems aboutthe intratumoral injection of radiosensitizer were discussed.
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Observation of intratumoral injection of radiosensitizer |
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| Xu Demen Sun Guoyan Sun Chaoyang Radiotherapy Center,Xijing Hospital,Fourth Military Medical University,Xi'an.Observation of intratumoral injection of radiosensitizer[J].Journal of Medical Colleges of PLA(China),1991(2). |
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| Authors: | Xu Demen Sun Guoyan Sun Chaoyang Radiotherapy Center Xijing Hospital Fourth Military Medical University Xi'an |
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| Institution: | Xu Demen Sun Guoyan Sun Chaoyang Radiotherapy Center,Xijing Hospital,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | The present study made in 92 mice showed that hydrogen peroxide com- pound injected directly into the tumor could to some extent sensitize the hypoxic cells of S180 solid tumor to radiate,for example,both the tumor regression rate and the mouse survival rate 40d after radiation in the hydrogen peroxide com- pound group were significantly greater than those in the radiation alone group. The increasing rate of tumor diameter in 10d was 77.10%,47.09%,and 47.47% -10.4% in groups of control,radiation alone,radiosensitizer alone,radiation and hydrogen peroxide compound,respectively.Some of the problems about the intratumoral injection of radiosensitizer were discussed. |
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| Keywords: | radiotherapy hypoxic cell intratumoral injection radiosensitizer |
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