Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features |
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| Authors: | Chang Wei Feng Li Dong Wang Lian Hua Jiao Bin Liu Shu Zheng Xin Ji Xie |
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| Institution: | (1) Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, Henan, China;(2) Department of Gastroenterology, The Second Affiliated Hostipal of Zhengzhou University, Zhengzhou, Henan, China;(3) Cancer Institute, Zhejing University, Hangzhou, China;(4) Department of Gastroenterology, Tong Ren Hospital, Capital Medical University, Beijing, China |
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| Abstract: | Background The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF) and the tumor suppressor p53 are fundamental play-markers of the angiogenic process. Overexpression of iNOS and VEGF has been shown to induce angiogenesis in tumors. P53 suppresses angiogenesis by down-regulating VEGF and iNOS. The correlation of expression of p53, VEGF and iNOS and clinical features in gastric carcinogenesis, however, has not been well characterized. |
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