5-HT2 Receptor Regulation of Extracellular GABA Levels in the Prefrontal Cortex |
| |
| Institution: | 1. Addiction Research Group (GRC, GRAC), IDIBAPS, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, Red de Trastornos Adictivos (RTA-RETICS), Barcelona, Spain;2. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) Lisbon, Portugal;3. Escola Nacional de Saúde Publica (ENSP) Universidade NOVA, Lisbon, Portugal;4. School of Health and Life Sciences, Glasgow Caledonian University, UK;5. Turkish Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkey;6. Alcohol, Drugs, Tobacco and Justice Division, Health Improvement Directorate, Public Health England, London, UK;1. NCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark;2. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA;1. Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, Wollongong, 2522, NSW, Australia;2. School of Medicine, University of Wollongong, Wollongong, 2522, NSW, Australia |
| |
| Abstract: | Monoamines, including both dopamine and serotonin, synapse onto prefrontal cortical interneurons. Dopamine has been shown to activate these GABAergic interneurons, but there are no direct data on the effects of serotonin on GABA release in the prefrontal cortex. We, therefore, examined the effects of the 5-HT2a/c agonist 1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI) on extracellular GABA levels in the prefrontal cortex of the rat. Local infusions of DOI dose-dependently increased cortical extracellular GABA levels. In addition, systemic DOI administration resulted in Fos protein expression in glutamic acid decarboxylase67-immunoreactive interneurons of the prefrontal cortex. These data indicate that serotonin, operating through a 5-HT2 receptor, acutely activates GABAergic interneurons in the prefrontal cortex. These data further suggest that there may be convergent regulation of interneurons by dopamine and serotonin in the prefrontal cortex. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
