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Atomic view of cosolute-induced protein denaturation probed by NMR solvent paramagnetic relaxation enhancement |
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| Authors: | Yusuke Okuno Janghyun Yoo Charles D. Schwieters Robert B. Best Hoi Sung Chung G. Marius Clore |
| Affiliation: | aLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520 |
| Abstract: | |
| Keywords: | protein– cosolute interactions, transient states, drkN SH3 native and unfolded states, NMR relaxation, replica exchange molecular dynamics |