A Novel Sprouted Oat Fermented Beverage: Evaluation of Safety and Health Benefits for Celiac Individuals |
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| Authors: | Natalia Aparicio-Garcí a,Cristina Martí nez-Villaluenga,Juana Frias,Laura Crespo Perez,Cristina Ferná ndez Ferná ndez,Claudio Alba,Juan Miguel Rodrí guez,Elena Peñ as |
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| Affiliation: | 1.Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain; (N.A.-G.); (C.M.-V.); (J.F.);2.Department of Gastroenterology, University Hospital Ramón y Cajal, Ctra. De Colmenar Viejo M-607, 28034 Madrid, Spain; (L.C.P.); (C.F.F.);3.Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain; (C.A.); (J.M.R.) |
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| Abstract: | The safety and health effects for celiac people of a novel beverage (SOFB) developed from sprouted oat flour by fermentation with Lactobacillus plantarum was explored. In vitro reactivity against anti-gliadin antibodies (AGA) and antioxidant/anti-inflammatory potential of SOFB in RAW 264.7 macrophages and Caco-2 cells were evaluated. Immunoreactivity against AGA and antioxidant activity were not detected in SOFB, but it exhibited significant anti-inflammatory activity. The tolerability and impact of SOFB consumption for 6 months on nutritional status and intestinal microbiota composition were investigated in 10 celiac adults (five treated and five control). SOFB consumption did not adversely affect duodenal mucosa nor the total IgA or anti-tissue transglutaminase antibody (IgA-tTG) levels in celiac participants, but it significantly decreased total cholesterol levels at all sampling times and folic acid levels at the end of the study compared to the placebo beverage. SOFB administration also shifted gut microbiota, leading to a higher relative abundance of some beneficial bacteria including the genera Subdoligranulum, Ruminococcus and Lactobacillus in the SOFB group. This study provides supporting evidence of the safety of health benefits of a novel functional beverage produced from sprouted oat. |
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| Keywords: | oat germination fermentation beverage celiac disease gluten-free diet microbiota |
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