Protein kinase C in IL- 2 signal transduction |
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Authors: | Yin Lu Dr Jon P Durkin |
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Institution: | (1) Cellular Neurobiology Group, Institute for Biological Sciences National Research Council of Canada, Building M-54, KIR 0R6 Ottawa, Ontario, Canada |
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Abstract: | Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation
of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have
been well worked out. By contrast, an understanding of the intracellular signals coupled to the IL-2 receptor and responsible
for mediating IL-2 effects in T-cells is far less developed, and the role that protein kinase C (PKC) may play in the various
cellular responses to IL-2 receptor activation is unclear. In this article we will discuss IL-2, its receptors, and IL-2 signal
transduction in relation to the physiological roles PKC activation may play in IL-2-mediated activation of T-cells and other
hematopoietic cells. |
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Keywords: | Interleukin-2 (IL-2) Protein kinase C Signal transduction |
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