舍曲林联合尼莫地平治疗脑卒中后抑郁的疗效研究

目的 探讨舍曲林联合尼莫地平治疗脑卒中后患者抑郁状态的疗效.方法 将115例脑卒中后抑郁患者随机分为观察组63例和对照组52例,观察组患者给予舍曲林+尼莫地平治疗,对照组患者单纯给予舍曲林治疗,在治疗前和治疗8周后分别用汉密尔顿抑郁量表(HAMD)、简易精神状态检查量表(MMSE)、临床神经功能缺损量表(CSS)、改良Barthel指数(MBI)评价两组患者的疗效.结果 两组患者疗效间差异有统计学意义(P<0.01),治疗后两组患者的HAMD、MMSE、CSS、MBI评分间差异均有统计学意义(P<0.05);两组患者治疗前、后组内比较HAMD、MMSE、CSS、MBI评分间差异有统计学意义(P<0.05).结论 舍曲林联合尼莫地平治疗脑卒中后抑郁有较好疗效,而且能够明显改善患者的认知能力和神经功能,提高其日常生活活动能力.

Efects of Sertraline Combined with Nimodipine on Post-stroke Depression

Objective To explore the effect of sertraline combined with nimodipine on post-stroke depression.Methods One hundred fifteen post-stroke depression patients were randomized into groups observation (n=63) and control (n=52).Observation group were given treatment of sertraline and nimodipine,control only sertraline.Hamilton Depression Rating Scale (HAMD),mini-mental state examination (MMSE),clinical neurological deficit scale (CSS),Barthel index (BI) were used to evaluate the efficacy in 2 groups.Results Afte...