Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia |
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| Authors: | Sauer Martin Rydholm Nancy Piatkowski John Lewis Victor Steiner Marie |
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| Affiliation: | a Department of Pediatrics and Division of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA. |
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| Abstract: | Toxicity from intermediate-dose methotrexate (MTX)is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity. |
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| Keywords: | Acute Lymphoblastic Leukemia Methotrexate Nephrotoxicity Obesity Renogram |
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