Intracytoplasmic Lumina in Human Oviduct Epithelium |
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Authors: | Haruo Hagiwara Nobuo Ohwada Toyoshi Fujimoto |
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Affiliation: | a Department of Anatomy, Gunma University School of Medicine, Maebashi, Gunma, Japanb College of Medical Care and Technology, Gunma University, Maebashi, Gunma, Japan |
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Abstract: | Intracytoplasmic lumina (ICL) in human oviduct epithelium were investigated with transmission electron microscopy. ICL were found in 43 out of 60 cases examined. They were ultra-structurally characterized by microvilli lining the lumina, periodic acid-thiocarbohydrazide-silver proteinate (PA-TCH-SP) staining-positive finely granular material in the lumina, and secretory vesicles in the cytoplasm surrounding the lumina. Although ICL were observed at various heights within the epithelium, they were mainly seen in basally located cells that did not face the oviduct lumen. Various stages of formation and development of ICL were observed in the basally located epithelial cells with secretory activities. Primary ICL were originated in the cytoplasm where the secretory granules were aggregated with smooth-surfaced tubular vesicles. Electron microscopic observations after PA-TCH-SP staining revealed that ICL were formed by fusion of the secretory granules with the tubular vesicles. ICL were enlarged into round profiles by further fusion of secretory granules and tubular vesicles, and subsequently opened to the oviduct lumen, or fused to each other to develop into large extracellular cysts within the epithelium. |
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Keywords: | intracytoplasmic lumina nitraepithelial cysts oviduct PA-TCH-SP staining secretory cells |
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