毒品依赖性海绵状脑白质病MRI诊断

目的 探讨毒品依赖性海绵状脑白质病的MRI特点。方法 对18例有中枢神经系统损害的戒毒患者行MRI平扫和增强扫描，分析病灶的分布，信号特点。结果 双侧额顶叶，枕叶，齿状核，皮质脊髓束，内囊后肢等部位显示异常信号，16例呈对称分布，2例呈局限性分布，T1WI上15例呈低信号，3例呈等信号；T2WI和FLAIR上均呈高信号，所有病灶均无明显异常强化，结论 MRI对毒品依赖性海绵状脑病诊断具有较高的敏感性和准确性。

Magnetic Resonance Imaging in the Diagnosis of the Drug-dependent Spongiform Leucoencephalopathy

Objective To investigate the characteristics of the drug-dependent cerebral spongiform leucoencephalopathy by MRI. Methods 18 patients who developed brain deteriorations in association with drug abuse underwent pre- and postcontrast MRI scans. The distribution and intensity of the lesions were analyzed. Results Abnormal intensities were revealed in the sites such as frontal, parietal, and occipital lobes, dentate nuclei , corticospinal tract and the posterior limbs of the internal capsule. A symmetrical distribution was found in 16 cases while a focal subtype was observed in 2 patients. On T1WI, hypointensity was seen in 15 patients and isointensity was displayed in 3 cases, and on T2WI, all lesions were manifested as hyperintensities. No enhancement was demonstrated. Conclusions MRI is sensitive and accurate in evaluating the spongiform leucoencepaloipathy induced by drug abstinence.