Lactate-stress testing in 54 patients with mitochondriopathy |
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| Authors: | J Finsterer H Eichberger C Jarius L Boltzmann |
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| Institution: | (1) Postfach 348, 1180 Wien, Austria, Europe e-mail: fij@2nr.nkr.magwien.gv.at, Tel.: +43-1-88000-260 or 261, Fax: +43-1-4781711, AT;(2) Institute for Research in Neuromuscular Disorders, (Director: Prof. B. Mamoli), Vienna, AT;(3) Institute of Anatomy, Neuromuscular Department, University of Vienna, Vienna, AT;(4) Institute of Neurology, University of Vienna, Vienna, Austria, AT |
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| Abstract: | Since there are only few data available about the lactate stress test in a group of patients with mitochondrial myopathy,
we investigated the sensitivity of this test in a larger cohort of such patients. Serum lactate was determined before, during
and after a 15 minute, constant 30 W workload on a bicycle ergometer in 47 controls, aged 15 to 72 years and 54 patients with
mitochondrial myopathy, aged 15 to 74 years. Lactate’s upper reference limits at rest, 5, 10, 15 minutes after starting, and
15 minutes after finishing the exercise were 2.0, 2.1, 2.1, 2.1 and 1.8 mmol/l respectively. The sensitivity of the lactate-stress
test was 69%. The lactate-stress test complements electrophysiological and bioptical findings and proved to be helpful in
diagnosing mitochondrial myopathy.
Received: 2 March 1999 / Accepted: 25 October 1999 |
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| Keywords: | Mitochondriopathy Bicycle ergometer Exercise stress test Metabolic disorder Lactacidosis |
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