|
|||||
|
|
Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid |
|
| Authors: | Ammazzalorso Alessandra Amoroso Rosa Bettoni Giancarlo Fantacuzzi Marialuigia De Filippis Barbara Giampietro Letizia Maccallini Cristina Paludi Domenico Tricca Maria L |
| Affiliation: | Department of Drug Sciences, University of Chieti, via dei Vestini, 66100 Chieti, Italy. |
| Abstract: | Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electron-withdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity. |
| Keywords: | Oxazolidin-2-ones Antibacterial activity Linezolid |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |