Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T |
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| Authors: | J S Burns L Lemoine N R Lemoine E D Williams D Wynford-Thomas |
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| Institution: | Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, UK. |
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| Abstract: | A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer. |
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