The vascular action of aqueous extracts of Foeniculum vulgare leaves |
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| Authors: | A S Abdul-Ghani R Amin |
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| Institution: | Biology and Biochemistry Department, Faculty of Science, Birzeit University, Occupied West Bank (via Israel). |
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| Abstract: | The vascular effects of aqueous extracts of Foeniculum vulgare leaves were tested using pentobarbital-anaesthetised rats. An intravenous administration of the lyophilized boiled water extract of leaves produced a significant dose-related reduction in arterial blood pressure, without affecting the heart rate or respiratory rate. In contrast the non-boiled aqueous extract showed very little hypotensive activity. The hypotensive effect of the boiling water extract appeared not to be mediated via adrenergic, muscarinic, ganglionic or serotonergic receptors; however, histamine antagonists inhibited the hypotensive effect in a dose-related manner. |
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