脑梗死患者血清高敏C反应蛋白与颈总动脉内中膜厚度的关系探讨

目的探讨脑梗死患者高敏C反应蛋白（hs-CRP）与颈总动脉内中膜厚度（IMT）的关系。方法将207例脑梗死患者按其IMT分成3个亚组（Ⅰ组：IMT≤0.92 mm;Ⅱ组：0.92 mm〈IMT≤2.00 mm;Ⅲ组：IMT〉2.00 mm）;根据是否存在颈总动脉硬化分为颈动脉硬化组和非颈动脉硬化组。将101名健康体检者作为对照组,测定各组空腹血清hs-CRP,并进行比较分析。结果脑梗死组血清hs-CRP水平明显高于对照组（P〈0.01）;脑梗死患者不同IMT组的hs-CRP水平存在差异,并随着IMT的增加而升高（P〈0.05、P〈0.01）;颈动脉硬化组的hs-CRP水平明显高于非颈动脉硬化组（P=0.003）。hs-CRP与IMT呈正相关（r=0.239,P=0.028）。结论 hs-CRP可作为反映颈动脉硬化发生和脑梗死危险性的指标。

Study on the correlation of serum high sensitive C reactive protein and carotid artery intima media thickness in patients with cerebral infarction

Objective To investigate the correlation of high sensitive C reactive protein（hs-CRP）and carotid artery intima media thickness（IMT） in patients with cerebral infarction.Methods 207 patients with cerebral infarction were classified into 3 groups according to the IMT（Group Ⅰ：IMT≤0.92 mm;Group Ⅱ：0.92 mmIMT≤2.00 mm;Group Ⅲ：IMT2.00 mm）.According to the occurance of carotid arteriosclerosis,there were carotid arteriosclerosis group and non-carotid arteriosclerosis group.101 healthy individuals were enrolled as healthy controls.The levels of hs-CRP in fasting serum were determined in every group.The difference was compared and analyzed.Results The level of hs-CRP of patients with cerebral infarction was higher than that of healthy control group（P0.01）.There was difference in the levels of hs-CRP between the different IMT groups,and the levels of hs-CRP increased with IMT（P0.05,P0.01）.The levels of hs-CRP in carotid arteriosclerosis group were significantly higher than those in non-carotid arteriosclerosis group（P=0.003）.The hs-CRP was positively correlated with IMT（r=0.239,P=0.028）.Conclusions hs-CRP is an important index for predicting carotid arteriosclerosis and cerebral infarction.