女性泌尿生殖道感染患者衣原体检测支原体培养及药敏分析

目的了解大连地区女性泌尿生殖道感染患者衣原体支原体感染及药敏情况。方法回顾性总结分析2008年1月—2009年10月大连医科大学附属第一医院及大连市妇产医院就诊的女性泌尿生殖道感染患者衣原体抗原检测支原体培养及药敏试验结果。衣原体抗原检测采用免疫层析法,支原体鉴定采用培养法,药敏试验采用药敏试剂盒。结果 4368例衣原体抗原检测患者感染沙眼衣原体（CT）152例（3.48%）;5530例支原体培养及药敏试验患者支原体感染2729例（49.35%）,其中单纯解脲脲原体（Uu）感染率最高占总感染率82.50%。支原体对13种抗菌药敏感性高的是多西环素、美满霉素、交沙霉素;耐药性高的是林可霉素、环丙沙星、罗红霉素。结论女性泌尿生殖道感染患者既有单纯感染又有混合感染,以单纯解脲支原体感染为主,其次为解脲支原体和人型支原体混合感染。临床应根据感染类型及抗菌药敏感性不同选择有效的抗生素进行治疗。

Detection of chlamydia and culture of mycoplasma and analysis of drug sensitivity in females with urogenital tract infection

Objective To investigate the status of chlamydia and mycoplasma infection in females with urogenital tract infection in Dalian area in order to provide some references for antibiotic selection for clinical practice.Methods We retrospectively analyzed the results of chlamydia detection and mycoplasma culture and drug susceptibility test in the female patients with urogenital tract inflammotion infection.Immuno-chromatography,culture method and antimicrobial susceptibility kit were applied respectively to detection of chlamydia,mycoplasma and microbial sensitive test.Results Chlamydia trachomatis（CT）was positive in 152 of 4368 patients（3.48%）in chlamydia detection;2729 of 5530（49.35%）patients were infected with mycoplasma in mycoplasma culture and microbial sensitive test,with a highest positive rate of 82.5% for single ureaplsma urealyticum（Uu）.The results of drug sensitivity showed that sensitivity of mycoplasma was the highest to minocycline,and doxycycline and josamycin were next to it.The drug resistance against lincomycin was the highest,and next to it were ciprofloxacin and rocithromycin.Conclusion The infection of chlamydia and mycoplasma in females with urogenital tract are single and mixed.Mycoplasma infection in urogenital tract are mainly caused by Uu and followed by mixture of Uu and human mycoplasma.Clinical doctors should select appropriate antibiotics for clinical treatment according to the differences in infection type and drugs sensitivity.