| 白细胞介素1受体拮抗剂基因多态性与2型糖尿病相关性的研究 |
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| 引用本文： | 周建中,周勇,钟文波,李惠武.白细胞介素1受体拮抗剂基因多态性与2型糖尿病相关性的研究[J].解放军医学高等专科学校学报,2010(2):235-237. |
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| 作者姓名： | 周建中 周勇 钟文波 李惠武 |
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| 作者单位： | [1]解放军兰州军区乌鲁木齐总医院综合科,新疆乌鲁木齐830000 [2]新疆医科大学基础医学院,新疆乌鲁木齐830011 |
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| 摘 要： | 目的探讨白细胞介素1受体拮抗剂（IL-1Ra）基因多态性分布与2型糖尿病的相关性。方法应用聚合酶链反应-产物长度多态性,检测74例2型糖尿病患者和99名对照者的IL-1Ra第2内含子的86个碱基（bp）数目可变重复片段（VNTR）多态性。结果IL-1Ra基因的5种不同组合等位基因,本研究发现A1A1、A1A2、A2A2、A1A3、A1A4、A2A36种基因型。IL-1Ra A1和A2基因型频率和等位基因频率在T2DM组和对照组比较差异无统计学意义（P〉0.05）。结论IL-1Ra内含子2基因多态性可能与2型糖尿病易感性无关。
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| 关 键 词： | 2型糖尿病 白细胞介素1 受体 多态性 |
Study on correlation between interleukin-1 receptor antagonist gene polymorphism and type 2 diabetes |
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| Zhou Jian-zhong,Zhou Yong,Zhong Wen-bo,Li Hui-wu.Study on correlation between interleukin-1 receptor antagonist gene polymorphism and type 2 diabetes[J].Clinical Journal of Medical Officer,2010(2):235-237. |
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| Authors: | Zhou Jian-zhong Zhou Yong Zhong Wen-bo Li Hui-wu |
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| Institution: | 1.Urumqi General Hospital of Lanzhou Military Region,PLA,Urumqi Xinjiang 830000,China;2.Pre-clinical Medical College of Xinjiang Medical University,Urumqi Xinjiang 830011,China) |
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| Abstract: | Objective To investigate the frequency of interleukin-1 receptor antagonist（IL-1Ra） gene polymorphism and its relationship to Type 2 diabetes.Methods The allele frequency and the genotype distribution of the polymorphism in the second intron of IL-1Ra gene were studied in 99 non-diabetic controls and 74 type 2 diabetes patients.Results In the five different constituent alleles of IL-lRa gene,six genotypes（A1/A1,A1/A2,A2/A2,A1/A3,A1/A4,A2/A3） were found in the study.There were no significant differences in frequencies of allele and genotype distribution in IL-1Ra variable number of tandem repeats（VNTR） between the type 2 diabetes patients and the controls.Conclusion The polymorphism of IL-1Ra intron 2 gene is not associated with the susceptibility of type 2 diabetes. |
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| Keywords: | diabetes mellitus type 2 interleukin-1 receptor polymorphism |
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