Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease |
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Authors: | T.G. BERGER,W.S. SAWCHUK,&dagger ,C. LEONARDI,&Dagger ,RIA LANGENBERG,J. TAPPERO,P.E. LEBOIT |
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Affiliation: | Department of Dermatology, School of Medicine, University of California, San Francisco 94143-0506. |
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Abstract: | Three males infected with the human immunodeficiency virus (HIV) were noted to have extensive flat warts of the face and/or body. In two there were also pityriasis versicolor-like lesions. Biopsies showed foamy, basophilic, distended cytoplasm in granular layer keratinocytes, characteristic of the human papillomavirus types seen in epidermodysplasia verruciformis. DNA hybridization techniques demonstrated the presence of HPV-type 8 in one patient and HPV 5 and 8 in another. Patients with immune suppression due to HIV infection may demonstrate the clinical features of epidermodysplasia verruciformis with the same potentially oncogenic HPV types. |
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