驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用

目的研究驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用。方法采用常温电晕充电的-500V,-1 000 V、-2 000 V聚丙烯为驻极体,1%、3%、5%的氮酮为化学促渗剂,利用透皮实验仪和HPLC,研究驻极体、氮酮以及驻极体联用氮酮对环孢菌素A溶液的透皮促渗作用。结果不同表面电压的驻极体以及不同浓度的氮酮均能提高环孢菌素A的累积渗透量;-1 000 V驻极体与1%氮酮联用,环孢菌素A的累积渗透量较1%氮酮单独使用略有提高。结论负极性驻极体、氮酮对环孢菌素A均有促渗作用,负极性驻极体与氮酮联用对环孢菌素A没有明显联合促渗作用。

Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro

Objective To study the penetration enhancement of electret and united Azone on cyclosporin A transdermalde livery in vitro.Methods Using corona charged -500 V,-1000 V and -2000 V polypropylene (PP) as electrets,1%,3% and 5% Azone as chemical enhancers,the transdermal behaviours of the cyclosporine A in solution were evaluated by modified Franze diffusion cell method.The concentration of cyclosporine A was measured by HPLC.Results All the electrets and chemical enhancers used in this study enhanced the cumulative penetration amount of the drug.The combination of -1000 V and 1% Azone showed a slight increase in cumulative penetration amount of the drug compared with that of the 1% Azone used alone.Conclusion Both the negative electret and Azone could enhance the transdermal delivery of cyclosporin A individually.But negative electret and Azone had no synergistic enhancing effect on cyclosporin A transdermal delivery.