血培养中病原菌的种类分布及耐药性分析

目的了解败血症患者病原菌分布及其常见病原菌耐药情况。方法败血症患者血培养标本经美国VersaTREK-240血培养仪培养，分离所得菌株用英国先德ARIS2X进行鉴定、药敏和K—B法药敏，比较排位前5位细菌耐特征。结果阳性率为17．0％，288株病原菌中，以表皮葡萄球菌、大肠埃希菌、人型葡萄球菌、金黄色葡萄球菌、肺炎克雷伯菌为主，病原菌对常用抗菌药物的耐药率较高，且医院感染菌的多药耐药率高于院外感染菌。结论病原菌以凝固酶阴性葡萄球菌为主，临床及时掌握败血症的细菌分布与其对抗菌药物的耐药现象和动态，对合理应用抗菌药物具有重要意义。

Distribution and drug resistance of pathogens isolated from blood

Objective To understand the distribution of common pathogens in patients with sepsis pathogen and it＇s drug resistance. Methods Pathogen was isolated from the patient＇s blood cultured by Versa of TREK - 240 instrument were tested by ARIS2X instrument and the K - B method to compare the ranking features of the top 5 bacterial resistance. Results Positive rate was 17.0% in 288 strains. The top 5 bacterias were Staphylococcus epidermidis, Escherichia toll, Staphylococcus hominis, Staphylococcus aureus, Klebsiella pneumonia. Pathogens resistant to commonly used antibiotics with a high rate, and the hospital infection rate of muhidrug resistance in bacteria was higher than out of hospital. Conclusion Pathogens mainly is coagulase - negative staphylococci. It is important for the doctor to grasp the distribution of the bacteria resistance and antimi- crohial drugs dynamic phenomenon on the rational use of antimicrobial agents.